A Secret Weapon For apl11
A Secret Weapon For apl11
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promyelocytic (M3) acute leukaemia; a variety of individuals express an unconventional morphologic spectrum intermediate concerning M2 and M3 AML.
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higher level of standard or dystrophic promyelocytes in peripheralblood and in bone marrow; no intracytoplasmic Auer rods; myeloperoxydasereaction favourable; immunocytochemical detection by having an anti-PLZF exhibits adistinct punctate nuclear distribution from the protein, suggesting itscompartmentalization during the nucleus.
Immediate detection of prognostically important fusion transcripts in acute leukemia working with simplified multiplex reverse transcription polymerase chain reaction.
ZBTB16-RARα variant of acute promyelocytic leukemia with tuberculosis: a circumstance report and evaluate of literature.
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Effective allogeneic bone marrow transplantation in the circumstance of variant acute promyelocytic leukemia with ZBTB16-RARA.
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A situation of acute promyelocytic leukaemia with abnormal cytological characteristics in addition to a ZBTB16-RARA fusion gene.
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Characterization of cryptic rearrangements and variant translocations in acute promyelocytic leukemia.
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the translocation consists of a breakpoint inside the zinc fingerregion of PLZF, with fusion of two zinc fingers to your RARa B location toform a five PLZF - three RARa fusion gene; the reciprocal five RARa - 3 PLZF genefuses seven zinc fingers towards the RARa location; RARas breakpoint takes place in1- on account of thealternative splicing of PLZF gene, two sorts of PLZF-RARa protein is usually detected: